1936 Tupelo–Gainesville tornado outbreak
On April 5–6, 1936, an outbreak of at least fourteen tornadoes struck the Southeastern United States, killing at least 454 people (with 419 of those deaths caused by just two tornadoes) and injuring at least 2,500 others. Over two hundred people died in Georgia alone, making it the deadliest disaster ever recorded in the state.
Source: Wikipedia — 1936 Tupelo–Gainesville tornado outbreak (CC BY-SA 4.0)