2003 Midwest mpox outbreak
An outbreak of human monkeypox (now known as mpox) began in May 2003 in the United States. By July, a total of 71 cases were found in six Midwestern states including Wisconsin (39 cases), Indiana (16), Illinois (12), Kansas (1), Missouri (2), and Ohio (1).
Source: Wikipedia — 2003 Midwest mpox outbreak (CC BY-SA 4.0)