AMPA receptor positive allosteric modulator

AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the AMPA receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system. == Medical applications == AMPAR PAMs have cognition- and memory-enhancing and antidepressant-like effects in preclinical models.