Allegheny Airlines Flight 853
On September 9, 1969, Allegheny Airlines Flight 853, a McDonnell Douglas DC-9 operating a regularly scheduled flight from Boston, Massachusetts, to St. Louis, Missouri, with stops in Baltimore, Maryland; Cincinnati, Ohio; and Indianapolis, Indiana, collided mid-air with a Piper PA-28 light aircraft near Fairland, Indiana.
Source: Wikipedia — Allegheny Airlines Flight 853 (CC BY-SA 4.0)