American Airlines Flight 1 (1941)
American Airlines Flight 1, dubbed "the New Yorker", was a regularly scheduled passenger flight. On October 30, 1941, when the route was a multiple stop flight from La Guardia Airport to Chicago Municipal Airport with intermediate stops at Newark, New Jersey; Buffalo, New York; Detroit, Michigan; and South Bend, Indiana; on the flight's leg between Buffalo and Detroit, the American Airlines Douglas DC-3 operating the route crashed into a wheat field approximately one half mile east of the town of Lawrence Station, Ontario, southwest of London.
Source: Wikipedia — American Airlines Flight 1 (1941) (CC BY-SA 4.0)