Applause sign
The applause sign is a behavioural indicator, relevant to neurodegenerative conditions, characterised by a patient's inability to execute the same number of hand claps as demonstrated by an examiner. == Background == The applause sign was first described by Dubois and colleagues in 1995, as "a simple test of motor control that helps to differentiate Progressive supranuclear palsy (PSP) from frontal or striatofrontal degenerative diseases", but has since appeared in various neurodegenerative conditions involving frontal lobe dysfunction.