Chloride shift
Chloride shift (also known as lineas phenomenon or Hamburger phenomenon, named after Hartog Jakob Hamburger) is a process which occurs in a cardiovascular system and refers to the exchange of bicarbonate (HCO−3) and chloride (Cl−) across the membrane of red blood cells (RBCs). == Mechanism == Carbon dioxide (CO2) is produced in tissues as a byproduct of normal aerobic metabolism.