Cholestenone 5alpha-reductase

In enzymology, cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes several chemical reactions of steroids in which a cholest-4-en-3-one is converted to the corresponding 5α-dihydrocholestan-3-one. For example, 5α-dihydroprogesterone is the product of the reduction of progesterone: The enzyme uses the cofactor, reduced nicotinamide adenine dinucleotide phosphate (NADPH).

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