Colibactin is a genotoxic metabolite produced by Escherichia coli and other Enterobacteriaceae. Colibactin is a polyketide peptide that can form inter-strand crosslinks in DNA. Colibactin forms DNA inter-strand cross-links by alkylation of adenine moieties on opposing DNA strands.
Colibactin is a genotoxic metabolite produced by Escherichia coli and other Enterobacteriaceae. Colibactin is a polyketide peptide that can form inter-strand crosslinks in DNA. Colibactin forms DNA inter-strand cross-links by alkylation of adenine moieties on opposing DNA strands.
Source: Wikipedia "Colibactin" · CC BY-SA 4.0
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