Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent (IC50 = 0.30 nM), selective, and non-competitive antagonist or negative allosteric modulator of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). CTX-B was originally developed by Cazorla M. and colleagues at Université Paris and Inserm in 2010, mimicking a specific structural loop in BDNF known for its functional selectivity.
Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent (IC50 = 0.30 nM), selective, and non-competitive antagonist or negative allosteric modulator of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). CTX-B was originally developed by Cazorla M. and colleagues at Université Paris and Inserm in 2010, mimicking a specific structural loop in BDNF known for its functional selectivity.
Source: Wikipedia "Cyclotraxin B" · CC BY-SA 4.0
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