Descendants of Ferdinand II of Aragon and Isabella I of Castile
Ferdinand II of Aragon's marriage to Isabella I of Castile produced seven children, five of whom survived birth and lived to adulthood. They arranged strategic political marriages for all of these children to powerful monarchs and well-connected women.
Source: Wikipedia — Descendants of Ferdinand II of Aragon and Isabella I of Castile (CC BY-SA 4.0)