Disuse supersensitivity, also pharmacological disuse supersensitivity or pharmacological denervation supersensitivity, is the increased sensitivity by a postsynaptic cell because of decreased input by incoming axons, e.g., due to the exposure to an antagonist drug. Jaffe and Sharpless pointed out that withdrawal syndrome after the cessation of a chronically used drug often shows an exaggerated response which is normally suppressed by the drug which produced a dependence.
Disuse supersensitivity, also pharmacological disuse supersensitivity or pharmacological denervation supersensitivity, is the increased sensitivity by a postsynaptic cell because of decreased input by incoming axons, e.g., due to the exposure to an antagonist drug. Jaffe and Sharpless pointed out that withdrawal syndrome after the cessation of a chronically used drug often shows an exaggerated response which is normally suppressed by the drug which produced a dependence.
Source: Wikipedia "Disuse supersensitivity" · CC BY-SA 4.0
Share this article: X · Bluesky