Endoplasmic-reticulum-associated protein degradation

Endoplasmic-reticulum-associated protein degradation (ERAD) designates a cellular pathway which targets misfolded proteins of the endoplasmic reticulum for ubiquitination and subsequent degradation by a protein-degrading complex, called the proteasome. == Mechanism == The process of ERAD can be divided into three steps: === Recognition of misfolded or mutated proteins in the endoplasmic reticulum === The recognition of misfolded or mutated proteins depends on the detection of substructures within proteins such as exposed hydrophobic regions, unpaired cysteine residues and immature glycans.

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