Embryological origins of the mouth and anus
The embryological origin of the mouth and anus is an important characteristic, and forms the morphological basis for separating bilaterian animals into two natural groupings: the protostomes and deuterostomes. In animals at least as complex as an earthworm, a dent forms in one side of the early, spheroidal embryo.
Source: Wikipedia — Embryological origins of the mouth and anus (CC BY-SA 4.0)