Mitochondrial DNA depletion syndrome

Mitochondrial DNA depletion syndrome (MDS or MDDS), or Alpers' disease, is any of a group of autosomal recessive disorders that cause a significant drop in mitochondrial DNA in affected tissues. Symptoms can be any combination of myopathic, hepatopathic, or encephalomyopathic.

Source: Wikipedia — Mitochondrial DNA depletion syndrome (CC BY-SA 4.0)