The Hille equation relates the maximum ionic conductance of an ion channel to its length and radius (or diameter), with the commonly used version implicitly takes into account a hemispherical cap. As it is ultimately based on a macroscopic continuum model, it does not take into account molecular interactions, and real conductances are often several times less than the predicted maximal flux.
The Hille equation relates the maximum ionic conductance of an ion channel to its length and radius (or diameter), with the commonly used version implicitly takes into account a hemispherical cap. As it is ultimately based on a macroscopic continuum model, it does not take into account molecular interactions, and real conductances are often several times less than the predicted maximal flux.
Source: Wikipedia "Hille equation" · CC BY-SA 4.0
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