Timeline of immunology
The following are notable events in the Timeline of immunology: 1550 BCE – The Ebers papyrus recommends placing a poultice on a tumor and then making an incision, which would induce infection and cause regression of the tumor Information in the Ebbers papyrus is thought to be derived from the 27th century BCE writings of the Egyptian physician Imhotep. 1549 – The earliest account of inoculation of smallpox (variolation) occurs in Wan Quan's (1499–1582) Douzhen Xinfa (痘疹心法) 1718 – Smallpox inoculation in Ottoman Empire realized by West, and Henry Kipkosgei, recorded the positive effects of variolation 1761 – A case of breast cancer cured after ulcerating and getting infected is reported by Lambergen 1796 – First demonstration of smallpox vaccination (Edward Jenner) 1808–1813 – First experimental demonstration of the germ theory of disease (Agostino Bassi, though he does not formally propose the theory until 1844) 1813 – Vautier reports spontaneous remission of cancer after gangrene infection (later to be known as Clostridium perfringens) 1829 – Another case of spontaneous remission of breast cancer after a patient refused surgery and the tumor ruptured, became infected and during a febrile illness with purulent discharge, it shrunk and disappeared after a few weeks.