Keratoendotheliitis fugax hereditaria

Keratoendotheliitis fugax hereditaria is an autosomal dominantly inherited disease of the cornea, caused by a point mutation in cryopyrin (also known as NALP3) that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. In keratoendotheliitis fugax hereditaria, patients suffer from periodical transient inflammation of the corneal endothelium and stroma, leading to short term obscuration of vision and, in some patients after repeated attacks, to central corneal stromal opacities.

Source: Wikipedia — Keratoendotheliitis fugax hereditaria (CC BY-SA 4.0)