The Kolbe nitrile synthesis, named for Hermann Kolbe, is a method for the preparation of alkyl nitriles by reaction of the corresponding alkyl halide with a metal cyanide. A side product for this reaction is the formation of an isonitrile because the cyanide ion is an ambident nucleophile.
The Kolbe nitrile synthesis, named for Hermann Kolbe, is a method for the preparation of alkyl nitriles by reaction of the corresponding alkyl halide with a metal cyanide. A side product for this reaction is the formation of an isonitrile because the cyanide ion is an ambident nucleophile.
Source: Wikipedia "Kolbe nitrile synthesis" · CC BY-SA 4.0
Share this article: X · Bluesky