Metalloenediynes are a family of compounds composed of an enediyne-containing ligand complexed to a transition metal that have potential use as anti-tumor therapeutics. Enediynes naturally undergo the Bergman cyclization to produce a 1,4-didehydrobenzene intermediate, whose thermal activation energy is stabilized by chelation of the ligand to a metal center, allowing for temperature regulation of this diradical formation.
Metalloenediynes are a family of compounds composed of an enediyne-containing ligand complexed to a transition metal that have potential use as anti-tumor therapeutics. Enediynes naturally undergo the Bergman cyclization to produce a 1,4-didehydrobenzene intermediate, whose thermal activation energy is stabilized by chelation of the ligand to a metal center, allowing for temperature regulation of this diradical formation.
Source: Wikipedia "Metalloenediynes" · CC BY-SA 4.0
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