N-Methyl-DOI
N-Methyl-DOI, also known as 2,5-dimethoxy-4-iodo-N-methylamphetamine (2,5-IDNA), is a serotonin receptor modulator of the phenethylamine, amphetamine, and DOx families related to the serotonergic psychedelic DOI. It is a potent agonist of the serotonin 5-HT2A receptor similarly to DOI. However, N-methyl-DOI was about 3.8-fold less potent than DOI as a serotonin 5-HT2A receptor agonist in terms of EC50Tooltip half-maximal effective concentration and showed reduced maximal efficacy compared to DOI (EmaxTooltip maximal efficacy = 64% vs. 83%).