Protein neddylation refers to the post-translational modification in which ubiquitin-like protein NEDD8 is covalently attached to the lysine residue of a target protein, which is catalyzed by a cascade of enzymes including UBA3, NAE1, UBE2M or UBE2F, and NEDD8 E3 ligases. Neddylation belongs to the overall class of protein-conjugating post-translational modifications, which includes other reactions such as ubiquitination, SUMOylation, and ISGylation.
Protein neddylation refers to the post-translational modification in which ubiquitin-like protein NEDD8 is covalently attached to the lysine residue of a target protein, which is catalyzed by a cascade of enzymes including UBA3, NAE1, UBE2M or UBE2F, and NEDD8 E3 ligases. Neddylation belongs to the overall class of protein-conjugating post-translational modifications, which includes other reactions such as ubiquitination, SUMOylation, and ISGylation.
Source: Wikipedia "Neddylation" · CC BY-SA 4.0
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