Norfolk Anti-Inoculation Riot of 1768
The Norfolk Anti-Inoculation Riot of 1768 was part of a series of riots across the English Colonies in the New World surrounding inoculation against smallpox. Many inhabitants of the colonies were against this relatively new approach to build immunity against smallpox.
Source: Wikipedia — Norfolk Anti-Inoculation Riot of 1768 (CC BY-SA 4.0)