Nucleotide exchange factor

Nucleotide exchange factors (NEFs) are proteins that stimulate the exchange (replacement) of nucleoside diphosphates for nucleoside triphosphates bound to other proteins. == Function == Many cellular proteins cleave (hydrolyze) nucleoside triphosphates – adenosine triphosphate (ATP) or guanosine triphosphate (GTP) – to their diphosphate forms (ADP and GDP) as a source of energy and to drive conformational changes.

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