The O'Brien–Fleming (OBF) boundary is a set of statistical thresholds used in group-sequential clinical trial designs. It allows analyses (typically by a data monitoring committee) of accumulating data at several pre-specified interim points while still preserving the overall Type I error rate (the chance of a false-positive result) that was specified for the final analysis.
The O'Brien–Fleming (OBF) boundary is a set of statistical thresholds used in group-sequential clinical trial designs. It allows analyses (typically by a data monitoring committee) of accumulating data at several pre-specified interim points while still preserving the overall Type I error rate (the chance of a false-positive result) that was specified for the final analysis.
Source: Wikipedia "O'Brien–Fleming boundary" · CC BY-SA 4.0
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