The PB2 E627K mutation in the viral polymerase of H5N1 (colloquially known as bird flu) allows for interaction with the mammalian gene ANP32A for optimal viral replication. Such host switching can be of grave public health concern.
The PB2 E627K mutation in the viral polymerase of H5N1 (colloquially known as bird flu) allows for interaction with the mammalian gene ANP32A for optimal viral replication. Such host switching can be of grave public health concern.
Source: Wikipedia "PB2 E627K mutation" · CC BY-SA 4.0
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