Pacific Air Lines Flight 773
Pacific Air Lines Flight 773 was a Fairchild F27A Friendship airliner that crashed on May 7, 1964, near San Ramon, California, a suburb in the East Bay, east of Oakland. The crash was most likely the first instance in the United States of an airliner's pilots being shot by a passenger as part of a murder–suicide.
Source: Wikipedia — Pacific Air Lines Flight 773 (CC BY-SA 4.0)