Psychoplastogen
Psychoplastogens, also known as plastogens (categorically) or neuroplastogens (nonhallucinogenic plastogens), are a group of small-molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single administration. Existing psychoplastogens with demonstrated therapeutic effects include ketamine, MDMA, scopolamine, and the serotonergic psychedelics, including LSD, psilocin (the active metabolite of psilocybin), DMT, and 5-MeO-DMT. Such compounds are under development for brain disorders, including depression, addiction, and PTSD. The ability to rapidly promote neuronal changes via mechanisms of neuroplasticity was recently discovered as the common therapeutic activity and mechanism of action.