Purine nucleoside phosphorylase deficiency

Purine nucleoside phosphorylase deficiency is a rare autosomal recessive metabolic disorder which results in immunodeficiency. == Signs and symptoms == In addition to the symptoms associated with immunodeficiency, such as depletion of T-cells, decline of lymphocyte activity, and an abrupt proliferation of both benign and opportunistic infections—PNP-deficiency is often characterized by the development of autoimmune disorders.

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