Pyruvate decarboxylation
Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate), is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. The reaction may be simplified as: Pyruvate + NAD+ + CoA → Acetyl-CoA + NADH + CO2 Pyruvate oxidation is the step that connects glycolysis and the Krebs cycle.