RU-27849
RU-27849, also known as 4,α-methylenetryptamine (4,α-methylene-T), is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship (SAR) studies of LSD. It shows affinity for serotonin receptors, including for the serotonin 5-HT1, 5-HT1A, and 5-HT2 receptors (IC50Tooltip half-maximal inhibitory concentration = 267–520 nM, 325–326 nM, and 1,964–2,900 nM, respectively).