Ryan International Airlines Flight 590

Ryan International Airlines Flight 590 was a cargo flight carrying mail for the United States Postal Service from Greater Buffalo International Airport (BUF) in Buffalo, New York, to Indianapolis International Airport (IND) in Indiana, with a stopover at Cleveland Hopkins International Airport (CLE) in Cleveland, Ohio. On February 17, 1991, the McDonnell Douglas DC-9-15RC operating the flight crashed on takeoff from Cleveland during icing conditions.

Source: Wikipedia — Ryan International Airlines Flight 590 (CC BY-SA 4.0)