Shwartzman phenomenon
Shwartzman phenomenon (also known as the Shwartzman reaction and the Sanarelli-Shwartzman reaction) is a rare hyperimmune reaction of the body to toxins associated with bacteria. == History == In 1923, Gregory Shwartzman, a doctor at Mount Sinai Hospital in New York City was trying to understand the Arthus reaction in terms of bacterial endotoxins and observed that after injecting a small dose of Bacillus typhosis (currently known as Salmonella enterica serovar Typhi into the skin of rabbits as a "priming dose" and then following 24 hours later with an intravenous injection of the same toxin caused a hemorrhagic necrosis at the original injection site in the skin.