Spanish conquest of New Granada
The Spanish conquest of New Granada refers to the conquest between 1525 and 1540 by the Spanish monarchy of the Chibchan-speaking nations of modern-day Colombia and Panama, mainly the Muisca and Tairona that inhabited present-day Colombia, beginning the Spanish colonization of the Americas. It is estimated that around 5.25 million people died as a result of Spanish Conquest, either by disease or direct conflict.
Source: Wikipedia — Spanish conquest of New Granada (CC BY-SA 4.0)