Mongol invasion of Kievan Rus'
The Mongol Empire invaded and conquered much of the Kievan Rus' in the mid-13th century, sacking numerous cities such as Ryazan, Yaroslavl, Pereyaslavl and Vladimir, including the largest: Kiev (50,000 inhabitants) and Chernigov (30,000 inhabitants). The siege of Kiev in 1240 by the Mongols is generally held to mark the end of the state of Kievan Rus', which had already been undergoing fragmentation.
Source: Wikipedia — Mongol invasion of Kievan Rus' (CC BY-SA 4.0)