Thermal amplitude (medical)
Thermal amplitude or thermal range refers to the temperature range in which a cold autoantibody or cold-reacting alloantibody binds to its antigen. Cold antibodies that can bind to antigen above 30 °C (86 °F) are considered potentially clinically significant and may lead to disease that occurs or worsens on exposure to low temperatures.
Source: Wikipedia — Thermal amplitude (medical) (CC BY-SA 4.0)