Tumor metabolome
The study of the tumor metabolism, also known as the tumor metabolome, describes the different characteristic metabolic changes in tumor cells. The characteristic attributes of the tumor metabolome are high glycolytic enzyme activities, the expression of the pyruvate kinase isoenzyme type M2, increased channeling of glucose carbons into synthetic processes, such as nucleic acid, amino acid and phospholipid synthesis, a high rate of pyrimidine and purine de novo synthesis, a low ratio of adenosine triphosphate and guanosine triphosphate to cytidine triphosphate and uridine triphosphate, low adenosine monophosphate levels, high glutaminolytic capacities, release of immunosuppressive substances and dependency on methionine.