Up-and-down procedure (or method) for toxicology tests in medicine is an alternative to the LD50 test, in which animals are used for acute toxicity testing. It requires fewer animals to achieve similar accuracy as the LD50 test because animals are dosed one at a time.
Up-and-down procedure (or method) for toxicology tests in medicine is an alternative to the LD50 test, in which animals are used for acute toxicity testing. It requires fewer animals to achieve similar accuracy as the LD50 test because animals are dosed one at a time.
Source: Wikipedia "Up-and-down procedure" · CC BY-SA 4.0
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