Blaise ketone synthesis
The Blaise ketone synthesis (named after Edmond Blaise) is the chemical reaction of acid chlorides with organozinc compounds to give ketones.[1][2] The reaction was claimed to bring excellent yields by Blaise, however, investigators failed to obtain better than moderate yields (50%).[3][4] Thus, the reaction is particularly ineffective in forming ketones from acyl chlorides. The reaction also works with organocuprates.[5][6] Reviews have been written.[7][8] == Reaction mechanism == The mechanism is sampled from the proposed mechanism for organocadmium compounds, given that the mechanisms are identical to one another the proposed mechanism for the reaction is the same as the one for organocadmium compounds[9][10].