The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with an α-bromoester and a nitrile.[1][2][3] The reaction was first reported by Edmond Blaise (1872–1939) in 1901. The final intermediate is a metaloimine, which is then hydrolyzed to give the desired β-ketoester.[4] Bulky aliphatic esters tend to give higher yields.
The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with an α-bromoester and a nitrile.[1][2][3] The reaction was first reported by Edmond Blaise (1872–1939) in 1901. The final intermediate is a metaloimine, which is then hydrolyzed to give the desired β-ketoester.[4] Bulky aliphatic esters tend to give higher yields.
Source: Wikipedia "Blaise reaction" · CC BY-SA 4.0
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