LEK-8841
LEK-8841, also known as N-methyl-N-(2-propynyl)-2-bromolysergamide or as 2-bromo-LEK-8842, is a monoamine receptor modulator of the lysergamide family related to 2-bromo-LSD. It is the 2-bromo derivative of LEK-8842. The drug shows affinity for serotonin 5-HT2 and α1-adrenergic receptors (Ki = 16.3 nM at 5-HT2) and acts as a silent antagonist of these receptors (A2 = 11.7 nM and 355 nM, respectively), with activity described as qualitatively similar to that of ketanserin but with greater selectivity for serotonin 5-HT2 receptors over α1-adrenergic receptors.